How cAMP Binding Causes Protein Kinase Activation

In spite of several decades of research, scientists have been unable to describe in rigorous quantitative terms the exact sequence of events that leads to activation of Protein Kinase A (PKA) by cyclic adenosine monophosphate (cAMP). But a research team at UCSD will soon publish results that explain this mechanism for a PKA isoform essential for proper functioning of the heart. See full article

Experimentation Meets Computation

A normal heart uses the complementary, alternating activities of “systolic” contraction and “diastolic” relaxation to pump blood throughout the body. So scientists are eager to understand the various factors that affect this process, including those that lead to heart disease and failure.

Each pumping cycle is initiated when calcium is released from storage sites in the muscle cells and binds to the protein troponin of the contractile filaments. Troponin is the protein complex that acts as a switch from relaxation to contraction in heart muscle and is the central regulator of the magnitude of contraction. See full article

Focus on Scientific Workflows

Ilkay Altintas’ work as Director of SDSC’s Scientific Workflow Automation Technologies Laboratory that has earned her particular acclaim. A scientific workflow is software composed of a series of computational and/or data manipulation tools or steps to produce an application that can be run especially on high-performance computers to produce data for subsequent analysis or comparison with other data sets. See full article

Remembering Anushka Michailova

Anushka Mihailova, a project scientist in the Department of Bioengineering at the University of California, San Diego died on May 17 after being struck by a hit-and-run driver while walking with her husband in Rancho Bernardo. Mihailova joined the department in 2000, where she was a researcher in the Cardiac Mechanics Laboratory led by bioengineering professor Andrew McCulloch in the UC San Diego Jacobs School of Engineering. Mihailova was a key investigator of the National Biomedical Computation Resource. See UCSD News Center article

Friends and colleagues in the Department of Bioengineering at UC San Diego have honored Dr. Anushka Michailova by establishing The Anushka Michailova Memorial Award as a tribute to her tireless commitment to undergraduate and graduate student research by recognizing outstanding student accomplishment in cardiovascular bioengineering research.

Learn more about what we do

NBCR is pleased to present two videos discussing recent development at the center. In the first video, Dr. Adarsh Krishnamurthy describes recent improvements to Continuity 6 highlighting features that enables patient specific modeling. In the second video, Dr. David Lee explains how NBCR is enabling research at remote locations through interactive visualization and discussion of data.

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