Cardiac Physiome Program

Printer Friendly Final Program (700 KB PDF)
Posters must not exceed 96x96 inches (243x243 cm).
Poster presenters may bring ONE PowerPoint or PDF slide to give a 1-minute Flash preview of their poster before lunch on Wednesday or Thursday.
Oral presentations may not exceed 15 mins including time for questions

  • 5:30-7:00 pm: Welcome Reception Patio
    • 7:30-8:30 am: Continental Breakfast Rousseau Foyer
    • 8:30-8:45 am: Opening Remarks Kon Tiki Ballroom
      Andrew McCulloch and Peter Arzberger
    • 8:45-9:30 am: Plenary Lecture Kon Tiki Ballroom
      Michael Regnier Seattle, Chair: Andrew McCulloch, La Jolla
      Combining Computational and Experimental Approaches to Study Myofilament Structure-Function in Normal and Diseased Cardiac Muscle
    • 9:30-9:45 am: Coffee Break Rousseau Foyer
    • 9:45-11:00 am: Cardiac Electrophysiology Kon Tiki Ballroom
      Chair: David Paterson, Oxford
      • Colleen Clancy, Davis
        Sex, Drugs and Funky Rhythms In Silico
      • Randall Rasmusson, Buffalo
        Markov Models of Use-dependence and Reverse Use-dependence during the Mouse Cardiac Action Potential
      • Satoshi Matsuoka, Kyoto
        Fine-Tuning of Cardiac Automaticity by Mitochondria Sodium-Calcium Exchange
      • Wayne Giles, Calgary
        Mathematical Models of the Action Potential in Human Ventricle in Relation to Safety Pharmacology
    • 11:00 - 11:15 am: Journal of Physiology Special Issue Discussion Kon Tiki Balltoom
      Chair: David Paterson, Oxford
    • 11:15 am-12:00 pm: Poster Flash Presentations Kon Tiki Balltoom
      Chair: Nic Smith, London
    • 12:00-1:45 pm: Posters and Boxed Lunch Rousseau Foyer and Suite
    • 1:45-3:00 pm: Myofilaments Kon Tiki Ballroom
      Chair: Henk ter Keurs, Calgary
      • Pieter de Tombe, Chicago
        Frank-Starling’s Law of the Heart: Myofilament length-Dependent Activation
      • Bert Tanner, Burlington
        Phosphorylation of S-282 in Cardiac Myosin Binding Protein-C is Sufficient to Nearly Double MgADP Release Rate from Myosin Cross-Bridges in Mouse Myocardium
      • Jeremy Rice, Yorktown Heights
        ODE-Based Model of Myofilaments: Keeping up with Times
      • Seiryo Sugiura, Tokyo
        Models of Co-operative Sarcomere Dynamics for Multi-Scale Heart Simulation
      • Paul Janssen, Columbus
        Cross-Bridge Kinetics in Intact Multicellular Cardiac Rat, Rabbit, and Human Muscles at Body Temperature
    • 3:45-5:00 pm: Excitation-Contraction Coupling Kon Tiki Ballroom
      Chair: Don Bers, Davis
      • Anushka Michailova, La Jolla
        Cell Membrane Microanatomy and L-Type Calcium Channel Distribution Modulate Calcium Dynamics in Ventricular Myocytes
      • Eric Sobie, New York
        Regulation of Cardiac Calcium Sparks: Insights Provided by Sensitivity Analysis of Stochastic Models
      • William Louch, Oslo
        Compensation and Decompensation of Cardiomyocyte Calcium Homeostasis During Heart Failure Progression
      • Daisuke Sato, Davis
        How does Unstable Intracellular Calcium Cycling Induce Spatially Discordant Alternans of Action Potential Duration in Tissue?
      • Peter Kohl, London
        Cardiac Deformation in the Normal Cycle and Electrical Responses to Point Stimulation
    • 5:15-6:30 pm: Posters and refreshments Rousseau Foyer and Suite
    • Dinner on your own. Happy Halloween

    • 7:30-8:45 am: Continental Breakfast Rousseau Foyer
    • 8:45-9:30 am: Plenary Lecture Kon Tiki Ballroom
      Natalia Trayanova Johns Hopkins University, Chair: James Bassingthwaighte, Seattle
      Modeling Cardiac Rhythm Disorders
    • 9:45-11:00 am: Metabolic and Regulatory Networks Kon Tiki Ballroom
      Chair: James Bassingthwaighte, Seattle
      • Andy Edwards, La Jolla
        Mechanisms of Early Afterdepolarizations Prior to Heart Failure in the CaMKIIδc Transgenic Mouse
      • Robert Harvey, Reno
        Arrhythmogenic Responses Triggered by Dynamic Changes in Autonomic Tone
      • Britton Boras, La Jolla
        Cooperativity in PKA Activation and cAMP Diffusion in Localized Microdomains of Adult Cardiomyocytes
      • Dan Beard, Milwaukee
        Control of Energy Metabolism and Substrate Utilization in Cardiac and Skeletal Muscle in Health and Disease
      • Jeffrey Saucerman, Charlottesville
        Network Reconstruction and Systems Analysis of Cardiac Myocyte Hypertrophy Signaling
    • 11:15 am-12:00 pm: Poster Flash Presentations Kon Tiki Ballroom
      Chair: Peter Hunter, Auckland
    • 12:00 pm-1:45 pm: Posters and Boxed Lunch Rousseau Foyer and Suite
    • 1:45-3:00 pm: Arrhythmia Mechanisms Kon Tiki Ballroom
      Chair: Natalia Trayanova, Baltimore
      • Sanjiv Narayan, La Jolla
        Localized Sources for Cardiac Fibrillation
      • Nathalie Virag, Lausanne
        Study of the Effect of Rapid Pacing from the Septum Area on Atrial Fibrillation
      • Richard Clayton, Sheffield
        Insights into the Mechanisms of Ventricular Fibrillation in the Human Heart: Experiments and Models
      • Alan Garfinkel, Los Angeles
        Beyond Channel Blocking: Anti-Arrhythmic Strategies from Bifurcation Theory
      • Molly Maleckar, Oslo
        Towards Modeling Arrhythmogenic Cardiomyopathy – Can Simulation Shed Light on a Complex Disease Process?
    • 3:45-5:00 pm: Ventricular Electromechanics Kon Tiki Ballroom
      Chair: Peter Hunter, Auckland
      • Eun Bo Shim, Chuncheon
        Computational Analysis of 15-Lead ECG System Using an Electromechanical Model of the Heart
      • Martyn Nash, Auckland
        Structural Imaging and Modelling the Mechanics of Heart Failure
      • Joakim Sundnes, Oslo
        Towards Patient-Specific Simulations of Strongly Coupled Cardiac Electro-Mechanics
      • Roy Kerckhoffs, La Jolla
        Integrating Patient-Specific Models with Growth and Remodeling
      • Steve Niederer, London
        Applying Personalised Computational Modelling to Clinical Cardiology
    • 5:15-7:00 pm: Posters Rousseau Foyer and Suite
    • 7:00 pm: Cocktails Aviary Ballroom Lobby
    • 7:30 pm: Conference Dinner Aviary Ballroom

    • 7:30-8:45 am: Continental Breakfast Rousseau Foyer
    • 8:45-9:30 am Plenary Lecture Kon Tiki Ballroom
      Nicolas Smith Kings College London, Chair: Peter Hunter, Auckland
      Of Mice and Men and Multi-scale Cardiac Modelling
    • 9:45-11:00 am: Clinical Image-Based Modeling Kon Tiki Ballroom
      Chair: Roy Kerckhoffs, La Jolla
      • Alistair Young, Auckland
        The Cardiac Atlas Project: Data Sharing for Population Modeling
      • Piet Claus, Leuven
        Shape Determines Non-Uniformity in Intramural Myocardial Mechanics In the Left Ventricle and Atrium
      • Alison Marsden, La Jolla
        Simulations for Improved Risk Stratification in Patients With Kawasaki Disease
      • Rob MacLeod, Salt Lake City
        Image Based Modeling of Atrial Arrhythmias
      • Gunnar Seemann, Karlsruhe
        Towards Personalized Clinical In-Silico Modeling of Atrial Anatomy and Electrophysiology
    • 11:00 am-12:00 pm: Closing Discussion and Future Plans Kon Tiki Ballroom
    • 12:00-1:00 pm: Boxed Lunch and Posters Rousseau Foyer and Suite


    POSTERS Rousseau Suite
    Poster Number Name Abstract Title Institution
    1 Arevalo, Hermenegild MRI-Based Models Of Patient-Specific Hearts With Ischemic Disease Can Predict SCD Risk Johns Hopkins University
    2 Bayer, Jason Spatially Discordant Alternans in Action Potential Voltage Increase Arrhythmia VulnerabilityiIn Human Heart Failure Johns Hopkins University School of Medicine
    3 Bear, Laura Inverse Analysis of Body Surface Potentials with Simultaneous Epicardial and Endocardial Mapping Auckland Bioengineering Institute
    4 Bellini, Chiara Computational Models of the Left Atrium for the Study of Atrial Fibrillation University of Calgary and Universite Bordeaux
    5 Blazevic, Bojan Can We Routinely Build Patient-Specific Models of CRT from Clinical Data? King's College London and Medical University of Graz
    6 Boyle, Patrick A Computational Framework for Simulating Cardiac Optogenetics Johns Hopkins University
    7 Bozorgizadeh, Mashid How is Dynamic Electrical Activity in the Heart Influenced by Tissue Structure? University of Sheffield
    8 Bugenhagen, Scott A Minimal Model of the Cardiac Ca2+/Calmodulin-Dependent Protein Kinase II Holoenzyme Medical College of Wisconsin
    9 Bueno Orovio, Alfonso Fraction Diffusion Models of Electrical Propagation in Cardiac Tissue: Electrotonic Effects and Modulated Dispersion of Repolarization University of Oxford
    10 Campbell, Stuart Aging Alters Ventricular Torsion and the Transmural Distribution of Myocyte Contractile Properties Yale University
    11 Cannon, Leah Odd-Skipped Up-Regulation Compensates for Aging-Related Changes in the Drosophila Heart Sanford Burnham Medical Research Institute
    12 Chabiniok, Radomir Myocardial Perfusion Modeling From Clinical Data King's College London
    13 Chang, Kelly Reduced Inactivation of Ryanodine Receptors in Atrial Fibrillation Drives Alternans at Slow Rates Johns Hopkins University
    14 Crozier, Andrew Determining Indicators of CRT Response Through Computation Modelling King's College London and University of Oxford
    15 de Oliveira, Bernardo Multiple Mechanoelectrical Feedback Mechanisms Affect Conduction Velocity Simula Research Laboratory
    16 Delhaas, Tammo CircAdapt: a User-Friendly Learning Environment for Cardiovascular (Patho)physiology Maastricht University
    17 Dewan, Sukriti Altered Cross-Bridge Relaxation Kinetics and Myofilament Phosphoproteome in Guinea Pig Heart Failure UC San Diego and Loyola University Chicago
    18 Fritz, Thomas Finite Element Analysis of the Contraction of the Heart within the Pericardium: A Frictionless Contact Problem Karlsruhe Institute of Technology
    19 Gan, Zhuohui MAAMD: A Workflow to Standardize Meta-Analyses of Affymetrix Microarray Data UC San Diego and Gladstone Institute of Cardiovascular Disease, UC San Francisco
    20 Gattoni, Sara Modelling Calcium Dynamics in the Rat Cardiac Myocyte Kings College London
    21 Gaur, Namit Multiscale Modeling of Ca2+ Cycling in Ventricular Myocytes: Whole-Cell Effects of Dyadic Properties Simula Research Laboratory and UC San Diego
    22 Gilbert, Stephen Myocardial 3D Structural Measurement: Comparison of DTMRI and Structure Tensor of High-Resolution MR University of Leeds
    23 Gonzales, Matthew Rotor Dynamics in Patient-Specific Biatrial Finite Element Models UC San Diego
    24 Hadjircharalambous, Myrianthi Weak Penalization Method- A Novel Approach to Incompressibility in Cardiac Mechanics King's College London
    25 Hake, Johan Altered Configurations of Ca2+ Release Units Cause Slowed Ca2+ Sparks in Failing Cardiomyocytes Simula Research Laboratory
    26 Himeno, Yukiko Development of an ANS-Regulated Cardiovascular Model Based on Cellular & Molecular Mechanisms Ritsumeikan University and Advanced Scientific Technology & Management Research Institute of Kyoto
    27 Jackson, Del Ray Simple Models of Muscle Regulation & Contraction University of Nevada School of Medicine
    28 Kekenes Huskey, Peter Calcium Dynamics in Rabbit Ventricular Myocytes UC San Diego
    29 Krishnamoorthi,Shankarjee Numerical Quadrature and Operator Splitting for Cardiac Electromechanics UC Los Angeles
    30 Krishnamurthy, Adarsh Multi-Scale Constitutive Model Of Active Myocardial Mechanics UC San Diego
    31 Krishnamurthy, Adarsh Acute CRT Response Correlates With Regional Variation In Work Density From Patient-Specific Ventricular Models UC San Diego
    32 Kung, Geoffrey Microstructural Border Zone Remodeling in the Post-Infarct Porcine Heart Measured by DT- and LGE-MRI UC Los Angeles
    33 Land, Sander Beta-Adrenergic Stimulation Maintains Cardiac Function in Serca2 Knockout Mice University of Oxford
    34 Lee, Jack Coronary Flow and Perfusion-Contraction Coupling in the Left Ventricle King's College London
    35 Li ,Pan A Model of Cardiac Thin Filament Activation with PKA and CaMKII Regulation UC San Diego
    36 Lichter, Justin Cytoskeletal Remodeling of Cardiac Ventricular Myocytes During Heart Failure University of Utah
    37 Lumens, Joost Left Ventricular Versus Biventricular Pacing in the Failing Heart with Left Bundle-Branch Block Maastricht University Medical Center
    38 Luo, Xiaoyu Finite Strain Modeling of Human Left Ventricle University of Glasgow, Xian Jiaotong University and New York University
    39 Marchesseau,Stephanie Cardiac Mechanical Model Calibration Based on the Unscented Transform INRIA
    40 Mirams, Gary Evaluation of an In-Silico Pro-Arrhythmic Safety Assay University of Oxford
    41 Moulton, Michael A Low Order Dynamical Model of the Left Ventricle for Clinical Applications UNMC
    42 Perotti, Luigi Computational Modeling Requirements to Produce an Accurate ECG UC Los Angeles
    43 Pfeiffer,Emily Stretch Modulation of Cardiomyocyte Conduction UC San Diego
    44 Piloto, Sarah Roles for Hif1a/Sima and Small Heat Shock Protein 23 (Hsp23) in Ischemia/Reperfusion-Induced Cardiac Injury in Drosophila Sanford Burnham Medical Research Institute
    45 Puglisi, Jose Feed Forward Modeling: Fixing the Force-Frequency Relationship UC Davis
    46 Quinn, T Alexander Transmural Electrophysical Heterogeneity Investigated by Dual Wavelength Optical Mapping Imperial College London
    47 Remme, Espen Determinants of Early Systolic Interventricular Septal Motion in Left Bundle Branch Block Olso University Hospital and King's College London
    48 Rivolo, Simone Biophysical Framework for Stimulating and Analyzing Coronary Wave Intensity Analysis King's College London
    49 Rocha, Bernardo Mechanical Effects on Simulated Electrograms of a Human Left Ventricular Wedge Federal University of Juiz de Fora-Brazil and Simula Research Laboratory
    50 Rodriguez, Blanca Capturing Parameter Uncertainty and Functional Variability in Cardiac Electrophysiology University of Oxford
    51 Sebastian, Rafael Modeling of Human torso for the Study and Characterization of Atrial Arrhythmias Universitat de Valencia
    52 Shimayoshi, Takao A Multiscale Cardiovascular Model on Energetic Efficiency ASTEM Research Institute of Kyoto
    53 Takeuchi, Ayako Mechanisms Underlying NCLX Reduction-Mediated Slowing of Cardiomyocyte Beating Rate Kyoto University
    54 Tangney, Jared Novel Role for Vinculin in Ventricular Myocyte Mechanics and Dysfunction UC San Diego
    55 Tran, Kenneth Demand-Driven Regulation of Cardiac Energy Supply Auckland Bioengineering Institute
    56 Trenor, Beatriz Effects of Electrical and Structural Remodeling on the Electrical Properties of the Failing Heart Universitat Politecnica de Valencia
    57 Villongco, Christopher Incorporating Human Ventricular Fiber Architecture in Patient-Specific Computational Models UC San Diego
    58 Vincent, Kevin Behavior of a High-Order Finite Element Solver for 3-D Anisotropic Reaction-Diffusion Models UC San Diego
    59 Wall, Sam Strongly Coupled Electromechanical Models of the Left Ventricle - Evaluation of Tissue Engineering Applications Simula Research Laboratory
    60 Walmsley, John mRNA Expression Levels Predict Cellular Electrophysiological Remodelling in Failing Human Hearts Using a Population-Based Simulation Study University of Oxford
    61 Wilhelms, Mathias Integration of Ion Current Measurement Data into Models of Cardiac Electrophysiology Karlsruhe Institute of Technology
    62 Wright, Adam The Role of Caveolae and Membrane Conformation in Load-Induced Ventricular Conduction Slowing UC San Diego
    63 Lamata, Pablo Population Analysis of Cardiac Anatomy Enabled by an Automatic Meshing Service King's College London
    64 Wang, Vicky Estimating In-Vivo Human Myocardial Fibre Strain Using FE Modelling of Diffusion Tensor and Tagged MRI Auckland Bioengineering Institute
    65 Maleckar, Molly Functional Consequences of Expression of Heart Sodium Channel Nav1.5 in Cardiac Fibroblasts and Myofibroblasts Simula Research Laboratory and University of Calgary